A Review on Cardiovascular Diseases Risk Prediction Approches Based on Machine Learning and Evolutionary Algorithms
DOI:
https://doi.org/10.21015/vtcs.v13i1.2091Keywords:
Machine Learning (ML), Hybrid ML-GA Models, Evolutionary Algorithm (EA), Genetic Algorithm, Evolutionary Machine Learning Models.Abstract
Across the world, 17 million people die from heart disease each year. Heart-related diseases were the main cause for about 19\% percent of deaths in Pakistan in 2016, the same has since now risen to 29%. As per most recent WHO statistics regarding prevalence of heart attacks in Pakistan, approximately more than two hundred thousand (200000) persons died in Pakistan in 2020 due to coronary heart disease, making up 16.49 percent of all fatalities. With a death rate of 193.56 per 100,000 inhabitants, Pakistan is ranked at number 30 in the world. Rising death rate due to heart disease can be minimized through detection at early stage. Different data mining approaches have made early detection of cardiac disease possible. Certain datasets are being used to retrieve useful information. Several machine learning techniques / models have been proved to be the most effective, accurate and profitable to detect cardiovascular disease at an early stage. However, the approach of machine learning and Genetic Algorithm (GA) with feature selection may aid in lowering the computational complexity of GA and increasing the effectiveness of its search for ideal solutions. Hence, there is dire need to apply such hybrid approach to get much more effective and accurate results. The goal of this survey paper is to review different papers related to CVD prediction at early stage by applying hybrid approach of ML Techniques with Genetic Algorithm. Moreover, the results obtained by the authors in reviewed papers are also examined. In the end, this survey will showcase the importance of the hybrid approach in improving accuracy of ML results.
References
Kanwal S, Rashid J, Nisar MW, Kim J, Hussain A. An Effective Classification Algorithm for Heart Disease Prediction with Genetic Algorithm for Feature Selection. In: 2021 Mohammad Ali Jinnah University International Conference on Computing (MAJICC). IEEE; 2021. doi:10.1109/MAJICC53071.2021.9526242.
Cleveland Clinic. Cardiovascular Disease [Internet]. 2023 [cited 2023 Nov 21]. Available from: https://my.clevelandclinic.org/health/diseases/21493-cardiovascular-disease
Srinadh V, Maram B, Mandala J, Maram RR. A Hybrid Machine Learning Model (NB-SVM) for Cardiovascular Disease Prediction. In: 2023 2nd International Conference on Sustainable Computing and Data Communication Systems (ICSCDS). IEEE; 2023. p. 7–13. doi:10.1109/ICSCDS56580.2023.10104808.
Jabbar MA, Deekshatulu BL, Chandra P. Classification of Heart Disease Using K-Nearest Neighbor and Genetic Algorithm. Procedia Technol. 2013;10:85–94. doi:10.1016/j.protcy.2013.12.340.
Mohan S, Thirumalai C, Srivastava G. Effective heart disease prediction using hybrid machine learning techniques. IEEE Access. 2019;7:81542–54. doi:10.1109/ACCESS.2019.2923707.
Kumar Y, Koul A, Singla R, Ijaz MF. Artificial intelligence in disease diagnosis: a systematic literature review, synthesizing framework and future research agenda. J Ambient Intell Humaniz Comput. 2023;14(7):8459–86. doi:10.1007/s12652-021-03612-z.
Ahsan MM, Luna SA, Siddique Z. Machine-Learning-Based Disease Diagnosis: A Comprehensive Review. Healthcare (Basel). 2022 Mar 1;10(3):541. doi:10.3390/healthcare10030541.
Tai KY, Dhaliwal J. Machine learning model for malaria risk prediction based on mutation location of large-scale genetic variation data. J Big Data. 2022 Dec;9(1):183. doi:10.1186/s40537-022-00635-x.
Ahmed R, Bibi M, Syed S. Improving Heart Disease Prediction Accuracy Using a Hybrid Machine Learning Approach: A Comparative study of SVM and KNN Algorithms. Int J Comput Inf Manuf (IJCIM). 2023;3(1). doi:10.54489/ijcim.v3i1.223.
Azmi J, Arif M, Nafis MT, Alam MA, Tanweer S, Wang G. A systematic review on machine learning approaches for cardiovascular disease prediction using medical big data. Med Eng Phys. 2022 Jul;105:103825. doi:10.1016/j.medengphy.2022.103825.
Dwarakanath L, Kamsin A, Rasheed RA, Anandhan A, Shuib L. Automated Machine Learning Approaches for Emergency Response and Coordination via Social Media in the Aftermath of a Disaster: A Review. IEEE Access. 2021. doi:10.1109/ACCESS.2021.3074819.
Pandey A, Gupta MP, Diwakar M, Dangi S, Madan P, Singh P. An Effective Machine Learning based Heart Disease Diagnosis Analysis. In: 2023 International Conference on Computational Intelligence, Communication Technology and Networking (CICTN). IEEE; 2023. p. 536–540. doi:10.1109/CICTN57981.2023.10141082.
Kavitha M, Gnaneswar G, Dinesh R, Sai YR, Suraj RS. Heart Disease Prediction using Hybrid Machine Learning Model. In: Proceedings of the 6th International Conference on Inventive Computation Technologies (ICICT). IEEE; 2021. p. 1329–1333. doi:10.1109/ICICT50816.2021.9358597.
Ganie SM, Malik MB. An ensemble Machine Learning approach for predicting Type-II diabetes mellitus based on lifestyle indicators. Healthc Anal. 2022;2:100092. doi:10.1016/j.health.2022.100092.
Abdeldjouad FZ, Brahami M, Matta N. A Hybrid Approach for Heart Disease Diagnosis and Prediction Using Machine Learning Techniques. In: Lecture Notes in Computer Science (LNCS). 2020. doi:10.1007/978-3-030-51517-1_26.
Telikani A, Tahmassebi A, Banzhaf W, Gandomi AH. Evolutionary Machine Learning: A Survey. ACM Comput Surv. 2022. doi:10.1145/3467477.
Mohan S, Thirumalai C, Srivastava G. Effective heart disease prediction using hybrid machine learning techniques. IEEE Access. 2019;7:81542–54. doi:10.1109/ACCESS.2019.2923707.
Ramesh TR, Lilhore UK, Poongodi M, Simaiya S, Kaur A, Hamdi M. Predictive Analysis of Heart Diseases with Machine Learning Approaches. Malays J Comput Sci. 2022;2022(Special Issue 1):132–48. doi:10.22452/mjcs.sp2022no1.10.
Rahman SMA, Ibtisum S, Bazgir E, Barai T. The Significance of Machine Learning in Clinical Disease Diagnosis: A Review. Int J Comput Appl. 2023;185(36):10–17. doi:10.5120/ijca2023923147.
Da Silva SF, Ribeiro MX, Batista Neto JDES, Traina-Jr C, Traina AJM. Improving the ranking quality of medical image retrieval using a genetic feature selection method. Decis Support Syst. 2011;51(4):786–96. doi:10.1016/j.dss.2011.01.015.
Castillo PA, Arenas MG, Merelo JJ, Rivas VM, Romero G. Multiobjective optimization of ensembles of multilayer perceptrons for pattern classification. In: Lecture Notes in Computer Science (LNCS). 2006. doi:10.1007/11844297_46.
Kwaśnicka H, Świtalski K. Discovery of association rules from medical data—classical and evolutionary approaches. 2006.
Ma PCH, Chan KCC, Yao X, Chiu DKY. An evolutionary clustering algorithm for gene expression microarray data analysis. IEEE Trans Evol Comput. 2006;10(3):296–314. doi:10.1109/TEVC.2005.859371.
Mangat V, Vig R. Novel associative classifier based on dynamic adaptive PSO: Application to determining candidates for thoracic surgery. Expert Syst Appl. 2014;41(18):8310–9. doi:10.1016/j.eswa.2014.06.046.
Song Q, Zheng YJ, Xue Y, Sheng WG, Zhao MR. An evolutionary deep neural network for predicting morbidity of gastrointestinal infections by food contamination. Neurocomputing. 2017 Feb;226:16–22. doi:10.1016/j.neucom.2016.11.018.
Wu CH, Chen TC, Hsieh YC, Tsao HL. A hybrid rule mining approach for cardiovascular disease detection in traditional Chinese medicine. J Intell Fuzzy Syst. 2019. doi:10.3233/JIFS-169864.
To C, Pham TD. Analysis of Cardiac Imaging Data using Decision Tree based Parallel Genetic Programming.
Chugh G, Kumar S, Singh N. Survey on Machine Learning and Deep Learning Applications in Breast Cancer Diagnosis. Cogn Comput. 2021;13(6). doi:10.1007/s12559-020-09813-6.
Predicting Heart Disease Risk Factors using Hawkins Dataset and Decision Tree Algorithms. Int J Mech Eng. 2023. doi:10.56452/6-3-674.
Ahsan MM, Luna SA, Siddique Z. Machine-Learning-Based Disease Diagnosis: A Comprehensive Review. Healthcare (Basel). 2022 Mar 1;10(3). doi:10.3390/healthcare10030541.
SVS College of Engineering, Institute of Electrical and Electronics Engineers. Prediction of Cardiovascular Disease Using Machine Learning Algorithms.
Singh P, Pal GK, Gangwar S. Prediction of Cardiovascular Disease Using Feature Selection Techniques. Int J Comput Theory Eng. 2022 Aug;14(3):97–103. doi:10.7763/IJCTE.2022.V14.1316.
Choudhury TH, Choudhury B. Automated Cardiovascular Disease Prediction Models: A Comparative Analysis. EAI Endorsed Trans Pervasive Health Technol. 2023;9(1). doi:10.4108/eetpht.8.3402.
Ganie SM, Pramanik PKD, Malik MB, Nayyar A, Kwak KS. An Improved Ensemble Learning Approach for Heart Disease Prediction Using Boosting Algorithms. Comput Syst Sci Eng. 2023;46(3):3993–4006. doi:10.32604/csse.2023.035244.
Louridi N, Douzi S, El Ouahidi B. Machine learning-based identification of patients with a cardiovascular defect. J Big Data. 2021 Dec;8(1). doi:10.1186/s40537-021-00524-9.
García-Domínguez A, et al. Diabetes Detection Models in Mexican Patients by Combining Machine Learning Algorithms and Feature Selection Techniques for Clinical and Paraclinical Attributes: A Comparative Evaluation. J Diabetes Res. 2023;2023:9713905. doi:10.1155/2023/9713905.
Yang J, Guan J. A Heart Disease Prediction Model Based on Feature Optimization and Smote-Xgboost Algorithm. Information (Switzerland). 2022 Oct;13(10). doi:10.3390/info13100475.
Chen T, Guestrin C. XGBoost: A Scalable Tree Boosting System. In: Proceedings of the 22nd ACM SIGKDD International Conference on Knowledge Discovery and Data Mining. 2016 Aug;785–94. doi:10.1145/2939672.2939785.
Yakovlev S, Bhatt CM, Patel P, Ghetia T, Mazzeo PL. Effective heart disease prediction using machine learning techniques. Algorithms (Basel). 2023;16(2). doi:10.3390/a16020088.
Eiben AE, Smith JE. Introduction. In: Introduction to Evolutionary Computing. 2003;1–14. doi:10.1007/978-3-662-05094-1_1.
Govindaraj M, Asha V, Saju B, Sagar M, Rahul. Machine Learning Algorithms for Disease Prediction Analysis. In: Proceedings of the 5th International Conference on Smart Systems and Inventive Technology (ICSSIT 2023). 2023. doi:10.1109/ICSSIT55814.2023.10060987.
Osama S, Shaban H, Ali AA. Gene reduction and machine learning algorithms for cancer classification based on microarray gene expression data: A comprehensive review. 2023. doi:10.1016/j.eswa.2022.118946
Ma PCH, Chan KCC, Yao X, Chiu DKY. An evolutionary clustering algorithm for gene expression microarray data analysis. IEEE Trans Evol Comput. 2006;10(3):296–314. doi:10.1109/TEVC.2005.859371
Zafar A, et al. Machine learning-based risk factor analysis and prevalence prediction of intestinal parasitic infections using epidemiological survey data. PLoS Negl Trop Dis. 2022;16(6). doi:10.1371/journal.pntd.0010517
Louridi N, Douzi S, El Ouahidi B. Machine learning-based identification of patients with a cardiovascular defect. J Big Data. 2021;8(1). doi:10.1186/s40537-021-00524-9
Kresoja KP, Unterhuber M, Wachter R, Thiele H, Lurz P. A cardiologist’s guide to machine learning in cardiovascular disease prognosis prediction. 2023. doi:10.1007/s00395-023-00982-7
Gupta N, Gupta D, Khanna A, Rebouças Filho PP, de Albuquerque VHC. Evolutionary algorithms for automatic lung disease detection. Measurement. 2019;140:590–608. doi:10.1016/j.measurement.2019.02.042
Eiben AE, Smith JE. Introduction. 2003. p.1–14. doi:10.1007/978-3-662-05094-11
Kanwal S, Rashid J, Nisar MW, Kim J, Hussain A. An effective classification algorithm for heart disease prediction with genetic algorithm for feature selection. In: Proc. 2021 MAJICC. IEEE; 2021. doi:10.1109/MAJICC53071.2021.9526242
Moiz AA, et al. A Machine Learning-Genetic Algorithm (ML-GA) approach for rapid optimization using high-performance computing. SAE Int J Commer Veh. 2018;11(5). doi:10.4271/2018-01-0190
Kangra K, Singh J. Comparative analysis of predictive machine learning algorithms for diabetes mellitus. Bull Electr Eng Inform. 2023;12(3):1728–1737. doi:10.11591/eei.v12i3.4412
Nagaraj NS, Lutimath M, Ramachandra HV, Raghav S. Prediction of heart disease using genetic algorithm. In: Proc. Second Doctoral Symposium on Computational Intelligence. Springer; 2021. p.66–75
R PL, Jinny SV, Mate YV. Early prediction model for coronary heart disease using genetic algorithms, hyper-parameter optimization and machine learning techniques. Health Technol. 2021;11(1):63–73. doi:10.1007/s12553-020-00508-4
Durga A, Phil DM. Enhanced prediction of heart disease by genetic algorithm and RBF network. 2015.
Abdeldjouad FZ, Brahami M, Matta N. A hybrid approach for heart disease diagnosis and prediction using machine learning techniques. In: Lecture Notes in Computer Science. Springer; 2020. doi:10.1007/978-3-030-51517-1_26
Guarneros-Nolasco LR, Cruz-Ramos NA, Alor-Hernández G, Rodríguez-Mazahua L, Sánchez-Cervantes JL. Identifying the main risk factors for cardiovascular diseases prediction using machine learning algorithms. Mathematics. 2021;9(20). doi:10.3390/math9202537
Navita, et al. Advanced hybrid machine learning model for accurate detection of cardiovascular disease. Int J Comput Intell Syst. 2025;18(1). doi:10.1007/s44196-025-00771-1.
Mohan S, Thirumalai C, Srivastava G. Effective heart disease prediction using hybrid machine learning techniques. IEEE Access. 2019;7. doi:10.1109/ACCESS.2019.2923707.
Detrano R, et al. International application of a new probability algorithm for the diagnosis of coronary artery disease. Am J Cardiol. 1989;64(5):304–310. doi:10.1016/0002-9149(89)90524-9.
Ramesh TR, Lilhore UK, Poongodi M, Simaiya S, Kaur A, Hamdi M. Predictive analysis of heart diseases with machine learning approaches. Malays J Comput Sci. 2022;Special Issue 1. doi:10.22452/mjcs.sp2022no1.10.
Bilgaiyan S, Ayon TI, Khan AA, Johora FT, Parvin M, Alam MJ. Heart disease prediction using machine learning. In: 2023 Int Conf Comput Commun Informatics (ICCCI). IEEE; 2023. doi:10.1109/ICCCI56745.2023.10128378.
SVS College of Engineering, IEEE. Proceedings of the 2018 International Conference on Current Trends towards Converging Technologies. 2018 Mar 1–3.
Yahaya L, Oye ND, Garba EJ. A comprehensive review on heart disease prediction using data mining and machine learning techniques. Am J Artif Intell. 2020;4(1):20. doi:10.11648/j.ajai.20200401.12.
Janosi A, Steinbrunn W, Pfisterer M, Detrano R. UCI Machine Learning Repository: Heart Disease Data Set. UCI; 1988.
Pandey A, Gupta MP, Diwakar M, Dangi S, Madan P, Singh P. An effective machine learning based heart disease diagnosis analysis. In: 2023 Int Conf Comput Intell Commun Technol Netw (CICTN). IEEE; 2023. p. 536–540. doi:10.1109/CICTN57981.2023.10141082.
What is a Confusion Matrix in Machine Learning. MachineLearningMastery.com [Internet]. 2024 Mar 29 [cited 2025 May 8]. Available from: https://machinelearningmastery.com/confusion-matrix-machine-learning/
Kangra K, Singh J. Comparative analysis of predictive machine learning algorithms for diabetes mellitus. Bull Electr Eng Inform. 2023;12(3):1728–1737. doi:10.11591/eei.v12i3.4412.
Downloads
Published
How to Cite
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License (CC-By) that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
This work is licensed under a Creative Commons Attribution License CC BY